Head Title

Individualized EEG/MEG targeted and optimized multi-channel transcranial electric stimulation in focal epilepsy

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This Masterclass is presented by Prof. Dr. rer. nat. Carsten H. Wolters, Vice-director of the Institute for Biomagnetism and Biosignalanalysis (IBB) and Professor at the Medical Faculty of the University of Münster, Germany. The webinar will "address the efficacy of targeted (by combined MEG/EEG source analysis) and optimized multi-channel transcranial direct current stimulation (mc-tDCS) as therapy for focal epilepsy in a double blind sham-controlled study. Targeted and optimized mc-tDCS is applied in pharmaco-resistant focal epilepsy patients. For mc-tDCS optimization we use our recently developed algorithm - Distributed Constrained Maximum Intensity (D-CMI) (Khan et al., 2022) - on a target region which is determined by mean of combined MEG/EEG source analysis of averaged interictal epileptiform discharges (IEDs) using realistic and skull-conductivity calibrated finite-element head modeling (Neugebauer et al., 2022). 

D-CMI was shown to be superior to standard bipolar tDCS in a somatosensory group study (Khan et al., 2023). A total amplitude of 4 mA is applied twice for 20 minutes, with a pause of 20 minutes in between, for five consecutive days. An Acti-Sham montage  is applied with the same regimen as treatment. We use a washout of 5 weeks between the two stimulation weeks. We investigate the effect of individually targeted and optimized mc-tDCS on IED frequency as well as seizure frequency and severity."


Dr. Wolters is currently working as Vice-director of IBB and Professor at the Medical Faculty of the University of Münster, Germany. He got his Master in Mathematics with minor in Medicine at RWTH Aachen, Germany, his PhD in Mathematics from the University of Leipzig, Germany, where he worked at the Max-Planck-Institutes for Mathematics in the Sciences and Human Cognitive and Brain Sciences, and his Habilitation in Mathematics at the University of Münster, Germany. He did a one-year PostDoc at the Scientific Computing and Imaging Institute, Salt Lake City, USA. His more than 100 publications reflect his research interests in bioelectromagnetism. 



1. Khan, A., Antonakakis, M., Vogenauer, N., Haueisen, J.,Wolters, C.H., Individually optimized multi-channel tDCS for targeting somatosensory cortex, Clin. Neurophysiol., 134:9-26, (2022), doi: 10.1016/j.clinph.2021.10.016.

2. Khan, A., Antonakakis, M., Suntrup-Krüger, S., Lencer, R., Nitsche, M.A. et al., Can individually targeted and optimized multi-channel tDCS outperform standard bipolar tDCS in stimulating the primary somatosensory cortex? Brain Stimulation, 16:1-16 (2023), doi: 10.1016/j.brs.2022.12.006

3. Neugebauer F, Antonakakis M, Unnwongse K, Parpalev J, Wellmer J, et al., Validating EEG, MEG and combined MEG and EEG beamforming for an estimation of the epileptogenic zone in focal cortical dysplasia, Brain Sciences, 12(1), 114 (2022). doi: 10.3390/brainsci12010114

4. Antonakakis, M., Kaiser, F., Rampp, S., Kovac, S., Wiendl, H., Stummer, W.,Gross, J., Kellinghaus, C., Khaleghi-Ghadiri, M., Möddel, G., Wolters, C.H.,Targeted and optimized multi-channel transcranial directcurrent stimulationfor focal epilepsy: An N-of-1 trial, Brain Stimulation, 17(2):221-223, Suppl mat: 26 pages (2024)https://doi.org/10.1016/j.brs.2024.02.010  



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